Centromere Evolution: Digging into Mammalian Primary Constriction
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چکیده
منابع مشابه
Centromeres Off the Hook: Massive Changes in Centromere Size and Structure Following Duplication of CenH3 Gene in Fabeae Species
In most eukaryotes, centromere is determined by the presence of the centromere-specific histone variant CenH3. Two types of chromosome morphology are generally recognized with respect to centromere organization. Monocentric chromosomes possess a single CenH3-containing domain in primary constriction, whereas holocentric chromosomes lack the primary constriction and display dispersed distributio...
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The centromere is a functional chromosome domain that is essential for faithful chromosome segregation during cell division and that can be reliably identified by the presence of the centromere-specific histone H3 variant CenH3. In monocentric chromosomes, the centromere is characterized by a single CenH3-containing region within a morphologically distinct primary constriction. This region usua...
متن کاملCOMMENTARY When is a centromere not a kinetochore?
The terms 'centromere' and 'kinetochore' were originally coined to describe the region(s) of each chromosome with which the spindle microtubules become associated (Rieger et al. 1976). In recent years, the term 'centromere' has largely come to be used by morphologists to describe the primary constriction of mitotic chromosomes. The term Tunetochore' has been used to refer to the circular plaque...
متن کاملPhysical map of the centromeric region of human chromosome 7: relationship between two distinct alpha satellite arrays.
A long-range physical map of the centromeric region of human chromosome 7 has been constructed in order to define the region containing sequences with potential involvement in centromere function. The map is centered around alpha satellite DNA, a family of tandemly repeated DNA forming arrays of hundreds to thousands of kilobasepairs at the primary constriction of every human chromosome. Two di...
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The mechanism of mitotic chromosome condensation is poorly understood, but even less is known about the mechanism of formation of the primary constriction, or centromere. A proteomic analysis of mitotic chromosome scaffolds led to the identification of CENP-V, a novel kinetochore protein related to a bacterial enzyme that detoxifies formaldehyde, a by-product of histone demethylation in eukaryo...
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تاریخ انتشار 2017